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e + n e e d + t o + p r o c e e d + t o + t h e + h i g h e r + d o s e % 0 a b r i a n + m a r c k x % 0 a o k a y + a n d + r e g a r d i n g + c h o p % 2 c + i t + s o u n d s + l i k e + t h e + e n t i r e + f o c u s e s + i s + o r p h a n + a n d + r a r e + i n d i c a t i o n s % 2 c + b u t + i s + i t + p o s s i b l e + a s + y o u + g o + t h r o u g h + t h e + i t e r a t i o n s + o f + p o t e n t i a l + c a n d i d a t e s + t h a t + y o u + l o o k + a t + n o n - o r p h a n + i n d i c a t i o n s % 3 f % 0 a j o h n + l e a m a n % 0 a i t % 2 7 s + a b s o l u t e l y % 2 c + p o s s i b l e % 2 c + b u t + o u r + d e a l + w i t h + t h e m + i s + s p e c i f i c a l l y + r a r e + a n d + o r p h a n + r e l a t e d + t o + c e n t e r + f o r + a p p l i e d + g e n o m i c s + i + t h i n k + w h e n + y o u + l o o k + a t + t h e + s l i d e s + t h a t + g a r r y + l a i d + o u t + y o u + h a v e + t h e s e + e x t r e m e + p h e n o t y p e s + w i t h + u n d e r l y i n g + g e n e t i c + m u t a t i o n + m a n y + t i m e s + t h o s e + m u t a t i o n s + a r e + f o u n d + o u t s i d e + o f + t h e + e x t r e m e + p h e n o t y p e + i n + o t h e r + s y n d r o m i c + d i s e a s e s % 0 a s o + i + t h i n k + o u r + i d e a + i s + v e r y + s p e c i f i c a l l y + g o + a f t e r + t h e + v e r y + n a r r o w + p a t i e n t + p o p u l a t i o n + a n d + t h e n + e x t e n d + o u t + t o + w h e r e + t h e + g e n e + l e a d s + u s + i n + o t h e r + s u b + p o p u l a t i o n + n o t + u n l i k e + t h e + w a y + c a n c e r + d e v e l o p m e n t + h a s + b e e n + d o n e + i n + t h e + l a s t + 1 0 % 2 c + 1 5 + y e a r s % 0 a b r i a n + m a r c k x % 0 a d o + y o u + h a v e + a + g e n e r a l + t i m e l i n e + o n + w h e n + y o u + h o p e + t o + i d e n t i f y + t h e + i n i t i a l + c a n d i d a t e s % 3 f % 0 a j o h n + l e a m a n % 0 a y e s % 2 c + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + b e e n + t e l l i n g + f o l k s + m i d - y e a r + t h e r e + i s + a + n u m b e r + o f + c a n d i d a t e s + i + t h i n k + g a r r y + l a i d + o u t + t h e + c r i t e r i a + t h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + u s i n g + a n d + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + p r i o r i t i z i n g + b a s e d + o n + t h e s e + c r i t e r i a + i + t h i n k + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + a + l i t t l e + d i f f e r e n t + f o r + u s + t h a n + w e + e x p e c t e d + w h e n + w e + s t a r t e d + t h e + r e l a t i o n s h i p % 0 a t h e r e + a r e + n e a r + t e r m + c l i n i c a l l y % 2 c + m o r e + c l i n i c a l l y + r e l e v a n t + o p p o r t u n i t i e s + t h a n + w e + e x p e c t e d + a n d + t h e r e + i s + a l s o + t h e + p o t e n t i a l + t o + r e p u r p o s e + e x i s t i n g + p r o d u c t s + i + c a n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 t + c a l l + t h e m + d r u g s + b e c a u s e + s o m e + o f + t h e s e + t h i n g s + h a v e + b e e n + s h e l v e d + a g a i n % 2 c + w e + r e a l l y + d i d n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 t + h a v e + o r + w a n t + t o + d e c i d e + i t + t o + w h e n + w e + s i g n e d + t h e + d e a l + p a c k % 0 a b r i a n + m a r c k x % 0 a o k a y % 2 c + a l l + r i g h t % 2 c + g r e a t + t h a n k s + g u y s % 0 a j o h n + l e a m a n % 0 a t h a n k + y o u % 2 c + b r i a n % 0 a o p e r a t o r % 0 a % 5 b o p e r a t o r + i n s t r u c t i o n s % 5 d + y o u + h a v e + a + f o l l o w - u p + q u e s t i o n + f r o m + t h e + l i n e + o f + t e d + t e n t h o f f + w i t h + p i p e r + j a f f r a y + y o u r + l i n e + i s + n o w + o p e n % 0 a t e d + t e n t h o f f % 0 a g r e a t + t h a n k + y o u + v e r y + m u c h + s o + m y + s e c o n d + q u e s t i o n + h a s + t o + d o + w i t h + c h o p % 2 c + a n d + i + r e a l l y + g e t + t h e + s e n s e + a n d + i + a p p r e c i a t e + t h e + w a y + y o u + k i n d + o f + c h a r a c t e r i z e d + t h a t + y o u + g u y s + m a y b e + j u s t + f o u n d + a n + e n t i r e + g o l d m i n e + i n + t e r m s + o f + j u s t + t h e + n u m b e r + o f + o p p o r t u n i t i e s + t h a t + y o u % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + g o i n g + t o + b e + a b l e + t o + g o + a n d + p u r s u e + i + m e a n + i + t h i n k + t h i s + i s + a + t r a n s f o r m a b l e + r e a l l y % 2 c + r e a l l y + e x c i t i n g + i n + t e r m s + o f + p r o v i d i n g + t h i s + d i s c o v e r y + e n g i n e + f o r + y o u + g u y s % 0 a s o + g a r r y % 2 c + i + g u e s s + m a y b e + k i n d + o f + a d d i n g + a + l i t t l e + b i t + m o r e + t o + t h e + d i s c u s s i o n + f r o m + y o u r + s i d e + h a v e + d o + y o u + p r i o r i t i z e + t h e s e + o p p o r t u n i t i e s + m o r e + s p e c i f i c a l l y % 3 f + a n d + u l t i m a t e l y % 2 c + h o w + d o + y o u + p u r s u e + t h e m + a l l % 3 f + i + m e a n % 2 c + i s + t h i s + s o m e t h i n g + h o w + a b o u t + p a r t n e r i n g + s t a r t + t o + f e e d + i n t o + t h e + l a r g e r + s t r a t e g y + h e r e + a s + y o u + c o n s i d e r + a l l + o f + t h e s e + e x c i t i n g + t a r g e t s + t h a t + a r e + g o i n g + t o + s t a r t + t o + m e r g e % 3 f % 0 a g a r r y + n e i l % 0 a g r e a t + q u e s t i o n s % 2 c + t e d + s o + t h e + p r i o r i t i z a t i o n + p r o c e s s + a s + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + s a i d + i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 m + r e a l l y + l o o k i n g + f o r + a + s t r o n g + p h e n o t y p e + w e l l + c h a r a c t e r i z e + a s + a n + i n i t i a l + p r o g r a m + b e c a u s e + w e + h a v e + t h e + b e s t + c h a n g e + o f + i d e n t i f y i n g + a + m e c h a n i s m + a n d + s h o w i n g + t h a t + w e + c a n + i n t e r v e n e + s o m e + o f + t h e + d i s e a s e s + t h a t + w e + s e e + d o w n + t h e r e + m a y + b e + p r e t t y + s e v e r e + m a l f o r m a t i o n + s t r u c k + h o l d + d i s e a s e + t h a t + s o r t + o f + t h i n g + w h e r e + a + d r u g + i n t e r v e n t i o n + i s n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 t + l i k e l y + t o + h e l p % 0 a t e d + t e n t h o f f % 0 a y e s % 0 a g a r r y + n e i l % 0 a s o + w e + t e n d + t o + s e t + t h o s e + a s i d e + a n d + f o c u s + o n + t h e + o n e s + w h e r e + m e t a b o l i c a l l y + o r + m e c h a n i s t i c a l l y + w e + c a n + i n t e r v e n e + w i t h + a + g e n e + t h e r a p y % 2 c + a + d r u g + o r + p r o t e i n + s o m e t h i n g + l i k e + t h a t + a n d + h a v e + a + g o o d + c h a n c e + o f + b e n e f i t i n g + t h e + p a t i e n t + a n d + t h e n % 2 c + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + l o o k i n g + f o r + t h i n g s + t h a t + w e + c a n + m e a s u r e + i n + t h e + s h o r t + t e r m + t h a t + w o u l d + a l l o w + u s + - + w o u l d + g i v e + u s + c o m f o r t + t h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + s e e i n g + a t + p h a r m a c o d y n a m i c % 2 c + i n + f a c t % 2 c + a l l o w + u s + t o + b e + a b l e + t o + a s s e s s + t h e + d o s e + a n d + a l s o + t o + a s s e s s + t h e + f e a s i b i l i t y + f o r + u s i n g + o u r + t a r g e t + s y s t e m + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + t r y i n g + a + d i f f e r e n t + t y p e + o f + a n + a p p r o a c h % 0 a a n d + t h e n % 2 c + y o u + a l s o + w a y + i n t o + t h a t + t h e + s i z e + o f + t h e + o p p o r t u n i t y % 2 c + t h e + c o m p e t i t i v e + l a n d s c a p e + a n d + a l l + o f + t h a t + g o e s + i n t o + i t + s o + i + t h i n k + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + h a r d + t o + b e + f o r m u l a t e % 2 c + b u t + w e + h a v e + t h e s e + c r i t e r i a + t h a t + w e + u s e + a n d + t h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + a p p l y i n g + r i g h t + n o w + a n d + i + t h i n k + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + g o i n g + - + t h e + t h i n g s + t h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + a b l e + t o + s e l e c t + - + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + g o i n g + t o + b e + a b l e + t o + s e l e c t + p r e t t y + w e l l % 0 a a n d + t h e n % 2 c + f r o m + t h e r e + w e + g o + i n t o + d e s i g n i n g + a + t r a n s l a t i o n a l + t y p e + o f + p r o g r a m + t h a t + g i v e s + u s + t h e + s h o r t e s t + p a t h + a n d + w h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + d o i n g + r i g h t + n o w + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + a l s o + s i t t i n g + d o w n + w i t h + t h e + c o n d i t i o n s + w h o + a r e + t r e a t i n g + t h e s e + p a t i e n t s + a n d + t a l k i n g + t o + t h e m + a b o u t + t h i s + a n d + t a l k i n g + a b o u t + t h e + - + t h i s + f r o m + t h e + p e r s p e c t i v e + o f + t h e + p a t i e n t s + o r + i n + s o m e + c a s e s + f o u n d a t i o n + o f + p a t i e n t + e f f i c a c y + g r o u p s + b e c a u s e + w e + k n o w + t h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + g o i n g + t o + n e e d + t h e i r + h e l p + i n + d e s i g n i n g + t h e + o v e r a l l + p r o g r a m % 0 a m i k e + c o l a % 0 a a n d + j u s t + t h e + c o u p l e + o f + t h i n g s + o n + t h e + r e l a t i o n s h i p + i t s e l f + a g a i n + e n r o l l m e n t + w e r e + a l l + o f + f o u r + m o n t h s + i n t o + i t + i + d o + t h i n k + t h e + o t h e r + s i d e + o f + w h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + d i s c o v e r i n g + i s + t h a t + t h e + c h a r a c t e r i z a t i o n + o f + m e c h a n i s m + i s + t h e r e + a n d + t h a t + t h e r e + m a y + b e + m o l e c u l e s + t o + a c t u a l l y + t r e a t + s o m e + o f + t h e s e + d i s e a s e s + j u s t + b e c a u s e + t h e y % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + b e e n + s h e l v e d + b e c a u s e + t h e y + w e r e + s t u d y i n g + i n + t h e + w r o n g + p a t i e n t + p o p u l a t i o n + d o e s n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 t + m e a n + t h a t + t h e y + c a n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 t + b e + v e r y + g o o d + d r u g s + t h a t + a r e + a c t u a l l y + r e l e v a n t + t o + t h i s + t y p e + o f + m u t a t i o n + a s + g a r r y + s a i d + m a n y + o f + t h e s e + d r u g s + s e l l + b e c a u s e + t h e y % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + n o t + s e t t i n g + t h e + r i g h t + p a t i e n t + p o p u l a t i o n % 0 a i f + y o u + l o o k + a t + t h e + p r o d u c t i v i t y + o f + t h e + g r o u p + o r + w o r k i n g + w i t h + t h e m + % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 3 + i t + i s + o f f + t h e + c h a r t s + i n + t h e + l a s t + 7 5 % 2 c + 8 + y e a r s + i t + h a d + o v e r + 4 0 0 + p u b l i c a t i o n s + w i t h + m o s t + p e o p l e + d o n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 t + r e a l i z e + t h a t + t h e r e + i s + a + 1 5 0 + t o + 2 0 0 + d i s c o v e r i e s + o n + r a r e + a n d + o r p h a n + d i s e a s e s + a + y e a r + a n d + m a n y + o f + t h e m + a c t u a l l y + c o m e + o u t + o f + t h i s + g r o u p + s o + s o m e + o f + t h e s e + t h i n g s + a r e + a c t u a l l y + n e w + a n d + n o v o % 2 c + t h e y + a r e + n o t + i n + t h e + n o r d % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + c a t a l o g u e % 2 c + t h e y + a r e + a c t u a l l y + n o v o + m u t a t i o n % 2 c + n o v o + p a t i e n t + p o p u l a t i o n % 0 a g i v e n + a l l + o f + t h a t % 2 c + t h e r e + i s + t r e m e n d o u s + v o l u m e + t h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + w o r k i n g + t h r o u g h + i n + b a c k l o g + i t + i s + a + l i t t l e + b i t + o v e r w h e l m i n g + i n + t i m e s % 2 c + b u t + t o + y o u r + l a s t + p o i n t + a b o u t + p a r t n e r i n g + a n d + s o m e + o f + t h e s e + t h i n g s + a c t u a l l y + h a v e + n a t u r a l + o w n e r s + t h a t + w o u l d + b e + a + f i t + a n d + i + t h i n k + a s + w e + a r e + o u t + t a l k i n g + t o + o t h e r + p o t e n t i a l + p a r t n e r s + b a s i c a l l y + o n + t h e + b i o p h a r m a + s i d e % 0 a t h e r e + h a s + b e e n + a + l o t + o f + i n t e r e s t + f o r + % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 3 + h o w + d o + w e + l e v e r a g e + t h i s + r e l a t i o n s h i p + t h e + g a r r y % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + p o i n t % 2 c + w e + c a n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 t + c h a s e + e v e r y + s i n g l e + o n e + o f + t h e s e + t a r g e t s % 2 c + b u t + t h e r e + i s + c e r t a i n l y + p e o p l e + i n t e r e s t e d + i n + v e r y + s p e c i f i c + a r e a s + t h a t + w o u l d + n a t u r a l l y + b e + w a n t i n g + t o + i n v e s t + i n + t h e s e + t y p e s + o f + d i s e a s e s + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + j u s t + s t a r t i n g + t h o s e + d i s c u s s i o n s + n o w % 0 a t e d + t e n t h o f f % 0 a r e a l l y % 2 c + r e a l l y + e x c i t i n g + k e e p + u p + t h e + g r e a t + w o r k + g u y s % 0 a g a r r y + n e i l % 0 a t h a n k s % 0 a t e d + t e n t h o f f % 0 a t h a n k + y o u % 0 a m i k e + c o l a % 0 a t h a n k + y o u % 2 c + t e d % 0 a o p e r a t o r % 0 a % 5 b o p e r a t o r + i n s t r u c t i o n s % 5 d + o u r + n e x t + q u e s t i o n + c o m e s + f r o m + t h e + l i n e + o f + m i k e + k i n g + w i t h + j m p + s e c u r i t i e s + y o u r + l i n e + i s + n o w + o p e n % 0 a m i k e + k i n g % 0 a h i % 2 c + g o o d + m o r n i n g % 2 c + g u y s + t h a n k s + f o r + t a k i n g + t h e + q u e s t i o n + c a n + y o u + h e a r + m e + o k a y % 3 f % 0 a m i k e + c o l a % 0 a y e a h % 2 c + y o u % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + v e r y + c r y s t a l + c l e a r % 0 a m i k e + k i n g % 0 a g r e a t + s o r r y % 2 c + i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 m + o n + t h e + r o a d + i + m a y + h a v e + m i s s e d + s o m e + o f + t h e + t h i n g s + i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 m + a b o u t + t o + a s k + a b o u t % 2 c + b u t + i + w a n t + t o + a s k + y o u + r e g a r d i n g + t h e + h y p o - r e s p o n d e r s + h o w + s h o u l d + w e + t h i n k + a b o u t + t h a t + p h y s i o l o g y + v e r s u s + e i t h e r + p e r i t o n e a l + o r + t h e + t r a n s p l a n t + p a t i e n t + p o p u l a t i o n + i n + t e r m s + o f + t h e + b i o l o g i c + f e e d b a c k + a n d + h o w + t h a t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + g o i n g + t o + i n f l u e n c e + t h e + w a y + y o u + t h i n k + a b o u t + d o s i n g + w i t h + t h e + m i c r o - o r g a n % 2 c + e t + c e t e r a % 3 f + a n d + t h e r e + a r e + a n y + s p e c i a l + c o n s i d e r a t i o n s + t h a t + w e + n e e d + t o + t h i n k + a b o u t + w i t h + r e g a r d + t o + t h a t + p o p u l a t i o n + v e r s u s + t h e + o t h e r s % 3 f % 0 a m i k e + c o l a % 0 a m i k e % 2 c + i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + l e t + g a r r y + t a k e + t h i s % 0 a g a r r y + n e i l % 0 a t h e + w a y + w e + s h o u l d + t h i n k + a b o u t + t h i s + b i o l o g i c a l l y + i s + - + y o u + w a n t + t o + h a v e + a + m u c h + m o r e + p h y s i o l o g i c + t y p e + o f + r e s p o n s e + t o + m a x i m i z e + t h e + o u t p u t + o f + t h e + e r y t h r o n + w h i c h + i s + t h e + p a r t + o f + t h e + m a r r o w + t h a t + p r o d u c e s + r e d + b l o o d + c e l l s + a n d + p r o b a b l y + t h e + l e a s t + p h y s i o l o g i c + w a y + y o u + c o u l d + p o s s i b l y + t h i n k + o f + t r e a t i n g + w i t h + d e p o + w o u l d + b e + t o + g i v e + v e r y + l a r g e + d o s e s + i n t e r v e n e s + i n t e r m i t t e n t l y + w h i c h + s t i m u l a t e s + t h e + a c u t e + l e a d i n g + p a r a d i g m + v e r s u s + g i v i n g + i t + m o r e + l i k e + t h e + r u n n i n g + t h e + b o d y + n a t u r a l l y + d o e s + m o r e + o r + l e s s + c o n t i n u o u s l y + a t + v e r y + l o w + d o s e % 0 a a n d + s o + a s + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + s e e n % 2 c + w e + a r e + a b l e + t o + a c h i e v e + m o r e + s t a b l e + h e m o g l o b i n + p r o d u c t i o n % 2 c + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + g o i n g + t o + s h o w + t h o s e + r e s u l t s + a t + t h e + a s g c + t e a m + m e e t i n g + i n + n e w + o r l e a n s + i n + m a y + v e r s u s + i n t e r m i t t e n t + e p o + i n j e c t i o n + a t + a + m u c h + l o w e r + o v e r a l l + e x p o s u r e % 0 a s o + t h e r e + i s + s o m e + h o p e + t h a t + p e o p l e + t h a t + n e e d + v e r y + h i g h + d o s e s + o f + i v + n e e d s + m u c h + v e r y + m u c h + l o w e r + d o s e s + c a n + h a v e + t h e + b e t t e r + r e s p o n s e + w i t h + c o n t i n u o u s + b u t + i + t h i n k + t h e + o t h e r + w a y + t h a t + w e + s h o u l d + t h i n k + a b o u t + i t % 2 c + a n d + t h e + w a y + t h a t + w e + a r e + t h i n k i n g + a b o u t + i t + i s + t h i s + t h e s e + h i g h + i n t e r m i t t e n t + d o s e s + a g a i n + s t i m u l a t i n g + m o r e + a c u t e + b l e e d i n g + c a n + b e + a s s o c i a t e d + i n + s o m e + p a t i e n t s + w i t h + v e r y + s e v e r e + h y p e r t e n s i o n + p o s s i b l y + r e l a t e d + t o + s o m e + o f + t h e + o t h e r + c a r d i o v a s c u l a r + e v e n t s % 0 a a n d + s o + a s + p a r t + o f + o u r + p r o g r a m + a n d + l o o k i n g + a t + p e r i t o n e a l + d i a l y s i s + a n d + o t h e r + p a t i e n t s % 2 c + i s + t o + s e e + n o w + w h e t h e r + o r + n o t + w e + c a n + h a v e + l e s s + o f + a n + i m p a c t + o n + b l o o d + p r e s s u r e + i n + t h e s e + p a t i e n t s % 0 a s o + y o u + c a n + i m a g i n e + t h a t + s o m e + o f + t h e + p a t i e n t s + w h o + a r e + g e t t i n g + v e r y + h i g h + d o s e s + m i g h t + a l s o + b e + s u f f e r i n g + s o m e + s i d e + e f f e c t s + a s + a + c o n s e q u e n c e + o f + t h a t + s p e c i f i c a l l y + h y p e r t e n s i o n + a n d + o t h e r + c a r d i o v a s c u l a r + e v e n t s % 0 a s o + t h a t % 2 7 s + s o m e t h i n g + w e + w a n t + t o + e x p l o r e % 2 c + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + t a l k e d + t o + t h e + a g e n c y + l i t t l e + b i t + a b o u t + t h a t + a n d + s e e + w h e t h e r + o r + n o t + w e + c a n + p r o v i d e + s o m e + b e n e f i t + t h e r e + t o + s o m e + o f + t h e s e + p a t i e n t s + w h o + h a v e + t h o s e + t y p e s + o f + r i s k % 0 a m i k e + k i n g % 0 a s u r e + i + m e a n + i + w o u l d + a g r e e + t h a t + s o m e t h i n g + r e s e m b l i n g + n o r m a l + p h y s i o l o g y + i s + d e s i r a b l e + w h e n e v e r + p o s s i b l e + i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 m + j u s t + w o n d e r i n g + d o + t h e s e + p a t i e n t s + h a v e + s u c h + d a m a g e + m a r r o w + w h a t e v e r + o r i g i n a l + b l a s t + f a i l u r e + o r + a n y t h i n g + l i k e + t h a t % 2 c + t h a t + a c c o u n t s + f o r + t h e + t y p e + o f + r e s p o n s i v e n e s s + t h a t + m a y + m a k e + t h e m + l e s s + r e s p o n s i v e + t o + a + m i c r o - o r g a n + w h a t + y o u + t h i n k + t h a t + o n c e + y o u + r e s t o r e + n o r m a l + e p o + l e v e l s + t h a t + i t + w i l l + c o m e + r i g h t + b a c k % 3 f % 0 a g a r r y + n e i l % 0 a r i g h t + w e l l + t h a t + i s + s o m e t h i n g + t h a t + w e + h a v e + t o + s t u d y + a n d + w e + a r e + s t u d y i n g + t h a t + i + t h i n k + t h e r e + i s + - + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + a + s o l i d + h y p o t h e s i s + t h a t + w e + c a n + t e s t + a n d + a s + f a r + a s + t h e + p a t i e n t s + t h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + t r e a t i n g + r i g h t + n o w % 2 c + m i k e + s h o w e d + y o u + t h a t + l o t + o f + t h e m + a r e + g e t t i n g + 2 0 % 2 c 0 0 0 + u n i t s + a + w e e k % 2 c + g e t t i n g + f a i r l y + h i g h + d o s e s + t h o s e + p e o p l e + t h e i r + m a r r o w + i s + p e r f e c t l y + c a p a b l e + o f + r e s p o n d i n g + t o + p r e t t y + l o w + c o n c e n t r a t i o n s + o f + e p o + a n d + w e + g i v e + t o + t h e m + t h a t + w a y % 0 a m i k e + c o l a % 0 a m i k e + w e + h a v e + p e o p l e + t h a t + a r e + r e a l l y + o n + t h e + - + i + w i l l + s a y + t h e + u p p e r + e d g e % 2 c + i % 2 7 m + s o r r y + t h e + l o w e r + e d g e + w h a t + w e + t h i n k + a s + t h e + h i g h + d o s e + a n d + t h e y + a r e + r e s p o n d i n g + w e l l % 0 a i + m e a n + y o u + a s k e d + a + v e r y + g o o d + q u e s t i o n + t h i s + i s + n o t + a + s i m p l e + d i s e a s e + o r + s i t u a t i o n % 2 c + y o u + h a v e + n u t r i t i o n a l + s t a t u s % 2 c + i r o n + s t o r e s + a n d + i n f l a m m a t i o n + t h a t + i m p a c t + t h e + a b i l i t y + t o + p r o d u c e + r e d + b l o o d + c e l l s + a n d + w h a t + l e a r n i n g + - + t h i s + i s + t r u l y + a + n o v e l + e x p e r i m e n t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + l e a r n i n g + a b o u t + h o w + t h i s + w o r k s + t o g e t h e r + a t + t r u e + p h y s i o l o g i c + l e v e l s + a n d + i + t h i n k + t h i s + i s + m o r e + o f + a n + a u t o l o g o u s + t r a n s p l a n t + t h a n + a n + i n j e c t i o n + o f + r e c o m b i n a n t + e p o % 0 a g a r r y + n e i l % 0 a o k a y + a n d + t h e n + i + j u s t + w o n d e r + i f + i + c o u l d + j u s t + d r i l l + d o w n + a + b i t + m o r e + o n + m d s + c a n + y o u + s a y + s p e c i f i c a l l y + w h a t + i s r a e l + a u t h o r i t i e s + w a n t + t o + s e e + f o r + y o u r + o u t l o o k + t h e r e % 3 f % 0 a m i k e + c o l a % 0 a t h e + r e g u l a t o r y + q u e s t i o n + r e a l l y + w a s + w o u l d + t h e y + a l l o w + u s + t o + d o + t h e s e + s t u d i e s + u n d e r + o u r + e x i s t i n g + i m p d + w h i c h + i s + t h e i r + e q u i v a l e n t + o f + a n + i n d + a n d + w e + i n i t i a l l y + t h o u g h t + t h a t + w e + w o u l d + b e + c o v e r e d + u n d e r + t h i s + b e c a u s e + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + e p o + i t + i s + a + s a m e + p r o d u c t % 2 c + t h e + i r v % 2 c + t h e + d m o h + r e v i e w + i t % 0 a s o + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + g o i n g + t o + g o + t h r o u g h + t h a t + p r o c e s s + w i t h + t h e m + a n d + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + n o t + e x p e c t i n g + a n y t h i n g + o u t + o f + t h e + o r d i n a r y + h e r e + b u t + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + j u s t + a n + e x t r a + s t e p + t h a t + w e + h a v e + t o + t a k e % 0 a m i k e + k i n g % 0 a o k a y + s o + n o + a d d i t i o n a l + d a t a + s c i e n c e + l i k e + t h a t % 2 c + t h e + c l i n i c a l + d a t a + t h a t + k e e p s + g e n e r a t e d % 3 f % 0 a m i k e + c o l a % 0 a n o % 2 c + t h e y + h a v e n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 t + r e q u e s t e d + a n y t h i n g + a t + t h i s + p o i n t % 2 c + w e + h a v e + b e e n + a b l e + t o + a n s w e r + a l l + t h e + q u e s t i o n s + b u t + w e + w i l l + b e + m e e t i n g + w i t h + d m o h + a n d + w e + w i l l + b e + d i s c u s s i n g + i t + w i t h + t h e m + a n d + w e + d o n % 2 7 t + a n t i c i p a t e + t h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + g o i n g + t o + n e e d + a n y t h i n g + m o r e + t h a n + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + a b l e + t o + p r o v i d e % 2 c + w e + h a v e + h u m a n + d a t a % 2 c + h u m a n + s a f e t y + d a t a + a n d + t h e + i n v e s t i g a t o r s + s e e m + t o + b e + c o m f o r t a b l e + w i t h + t h a t + b u t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + w o r k + w i t h + t h e m + a n d + w i l l + d o + w h a t e v e r + t h e y + r e q u i r e % 0 a m i k e + k i n g % 0 a o k a y + j u s t + a + q u i c k + q u e s t i o n + o n + c h o p + a g a i n + n o t + a s k + y o u + t o + r e v e a l + a l l + y o u r + s e c r e t s + b u t + t h i s + i s + f a r + a s + t h e + w a y + w e + s h o u l d + t h i n k + a b o u t + t h e s e + t a r g e t e d + d i s e a s e + a r e a s + a r e + t h e y + m o n o g e n i c + d i s e a s e % 2 c + a r e + t h e y + s o r t + o f + c l a s s i c + e n z y m e + r e p l a c e m e n t + d i s e a s e s % 2 c + n o n e + o f + t h e + a b o v e % 2 c + a l l + o f + t h e + a b o v e % 0 a m i k e + c o l a % 0 a i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + i n + a l l + o f + t h e + a b o v e % 0 a g a r r y + n e i l % 0 a t h e + b e s t + w a y + t o + a n s w e r + t h e + q u e s t i o n + t o + m e + i s + t o + l o o k + a t + t h e + 4 0 0 + p u b l i c a t i o n s % 2 c + n o t + t h a n + a n y b o d y + n e e d s + t o + d o + t h a t + b u t + y o u + n a m e + a n + a r e a + t h e y + h a v e + a + d i s c o v e r y + i n + t h a t + a r e a + a l t h o u g h + i t % 2 7 s + - + e v e r y t h i n g + f r o m + c o m p l e x + n e t w o r k s + o f + g e n e t i c + m u t a t i o n s + s o u n d + t h r o u g h + m o n o g e n i c + m e n d e l i a n + d i s e a s e s % 0 a s o + i + t h i n k + f o r + u s + w e + r e a l i z e d + w e + n e e d + t o + b e + f l e x i b l e + i n + o u r + s o l u t i o n s + t o + t h e s e + p r o b l e m s + a n d + w e + l o v e + o u r + t e c h n o l o g y % 2 c + w e + c a n + t a r g t + p l a t f o r m + t h a t % 2 7 s + g r e a t % 2 c + s o + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + g o i n g + t o + h a v e + t o + r u n + o u r + p o r t f o l i o + o f + c a p a b i l i t y + t o + a c t u a l l y + t r e a t + s o m e + o f + t h e s e + d i s e a s e s % 0 a s o % 2 c + l u c k i l y + t h e r e + i s + a + l o t + o f + s h e l v e d + m o l e c u l e s + o u t + t h e r e + a n d % 2 c + t h e + s t o p + t h a t + w e + t h i n k + i t + b r i n g + i m m e d i a t e l y + a b l e + t o + t r e a t + t h e s e + p a t i e n t s + - + i n + a n y w a y + m o s t + o f + t h e + p a t i e n t s + w e + a r e + t a l k i n g + a b o u t + h a v e + b u i l d i n g + o u t + r e c o u r s e + % 5 b i n d i s c e r n i b l e % 5 d % 0 a j o h n + l e a m a n % 0 a a n d + w e + h a v e + a + l o t + o f + c a p a b i l i t i e s + r e l a t e d + t o % 2 c + t h e + r e c o m b i n a n t + p r o t e i n + a n d + m o l e c u l a r + b i o l o g y % 2 c + w h i c h + i s + c o r e + t o + o u r + m a i n + t e c h n o l o g y + p l a t f o r m + s o + w e + c a n + b r i n g + t h a t + t h e + b e a r + a s + w e l l % 0 a m i k e + k i n g % 0 a r i g h t + s o + i t % 2 7 s + - + m i k e % 2 c + y o u + s a i d + a t + c o u p l e + t i m e s + a b o u t + s h e l v e d + p r o g r a m s % 2 c + c a n + y o u + s a y + w h e t h e r + t h e + p r o g r a m s + a r e + s h e l v e d + b e c a u s e + l a c k + o f + a + s u i t a b l e + d e l i v e r y + v e h i c l e + o r + i n a b i l i t y + t o + m a n u f a c t u r e + a g a i n + t h i s + h a d + a n d + a l l + t h e + a b o v e + k i n d + o f + a n s w e r % 0 a m i k e + c o l a % 0 a y e s % 2 c + i + t h i n k + t h e r e + a l l + t h e + a b o v e + b u t + a g a i n + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + l o o k i n g + f o r + p r o g r a m s + o b v i o u s l y + t h a t + h a v e + c l e a n + s a f e t y + p r o f i l e s % 2 c + t h a t + h a v e % 2 c + s o m e + k n o w n + e f f e c t + b u t + w h e r e + t h e y + w e r e + s t u d i e d + i n + a + v e r y + d i v e r s i f i c a t i o n + p o p u l a t i o n + a n d + h e t e r o g e n e o u s + p o p u l a t i o n + a n d + s o + t h e + c o m p a n y + g o t + b a c k + a + v e r y + w e a k + s i g n a l + o n + t h e + e f f i c a c y + s i d e % 0 a t h e r e + i s + s o m e t h i n g + t h a t % 2 7 s + d o w n + o n + t h e + e f f i c a c y + s i d e + i s + o f + g r e a t + i n t e r e s t + t o + u s % 2 c + a s + i n + f a c t + w e + c a n + s t r a t i f y + t h e + p a t i e n t s + a s + g a r r y + l a i d + o u t + i n + h i s + a p p r o a c h + h e r e + w e + s t r a t i f y + t h e + p a t i e n t s + w i t h + t h e + g e n e t i c + b i o m a r k e r % 2 c + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + g o i n g + t o + g e t + a + m u c h + h i g h e r + r e s p o n s e + a g a i n + a s + y o u + l o o k + t h r o u g h + c a n c e r + d i a g n o s t i c s + a n d + d e v e l o p m e n t s % 2 c + a n d + t h e + w a y + i t s + r e a l l y + h a s + g o n e + i n + t h e + l a s t + t e n + y e a r s + o r + s o % 0 a w e + i d e n t i f y + t h e + p a t i e n t + t h a t + t h e + d r u g + i s + g o i n g + t o + w o r k + i n + b a s e d + o n + a + b i o m a r k e r + a n d + i t s + b e e n + h a r d + t o + t r a n s l a t e + t h a t + i n t o + o t h e r + t h e r a p e u t i c + a r e a s + b u t + i + t h i n k + w e + h a v e + r e a l + s h y + h e r e + a s + g a r r y + h a s + s a i d % 2 c + t h e + t o o l s + a r e + t h e r e % 2 c + d a 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