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e l i g i b l e + p a t i e n t s + i n + t h e + u s + a n d + 3 7 % 2 c 0 0 0 + g l o b a l l y % 2 c + f o u r + n e w + % 0 a + + + + + + t h e r a p i e s + h a v e + b e e n + a p p r o v e d + i n + t h e + p a s t + f i v e + y e a r s 5 + d e s p i t e + % 0 a + + + + + + t h e + a v a i l a b i l i t y + o f + s e v e r a l + t h e r a p e u t i c + o p t i o n s % 2 c + h o w e v e r % 2 c + c u r r e n t l y + % 0 a + + + + + + a p p r o v e d + a g e n t s + h a v e + s h o w n + l i t t l e + d i f f e r e n t i a t i o n + i n + t e r m s + o f + e f f i c a c y + % 0 a + + + + + + a n d + h a v e + d e m o n s t r a t e d + o n l y + m o d e s t + p f s + b e n e f i t + i n + p a t i e n t s + r e f r a c t o r y + t o + % 0 a + + + + + + s u n i t i n i b % 2 c + a + c o m m o n l y - u s e d + f i r s t - l i n e + t h e r a p y % 0 a % 0 a % 0 a + + + + + + + + + + + + + + + + + + % 0 a + + + + + + + + a b o u t + c a b o z a n t i n i b % 0 a + + + + + + % 0 a % 0 a + + + + + + + + + + + + + + + + + + c a b o z a n t i n i b + i n h i b i t s + t h e + a c t i v i t y + o f + t y r o s i n e + k i n a s e s + i n c l u d i n g + m e t % 2 c + % 0 a + + + + + + v e g f r s + a n d + r e t + t h e s e + r e c e p t o r + t y r o s i n e + k i n a s e s + a r e + i n v o l v e d + i n + b o t h + % 0 a + + + + + + n o r m a l + c e l l u l a r + f u n c t i o n + a n d + i n + p a t h o l o g i c + p r o c e s s e s + s u c h + a s + % 0 a + + + + + + o n c o g e n e s i s % 2 c + m e t a s t a s i s % 2 c + t u m o r + a n g i o g e n e s i s % 2 c + a n d + m a i n t e n a n c e + o f + t h e + % 0 a + + + + + + t u m o r + m i c r o e n v i r o n m e n t % 0 a % 0 a % 0 a + + + + + + + + + + + + + + + + + + c o m e t r i q % c 3 % 8 2 % c 2 % a e + % 2 8 c a b o z a n t i n i b % 2 9 + i s + c u r r e n t l y + a p p r o v e d + b y + t h e + u s + f o o d + a n d + d r u g + % 0 a + + + + + + a d m i n i s t r a t i o n + f o r + t h e + t r e a t m e n t + o f + p r o g r e s s i v e % 2 c + m e t a s t a t i c + m e d u l l a r y + % 0 a + + + + + + t h y r o i d + c a n c e r + % 2 8 m t c % 2 9 % 0 a % 0 a % 0 a + + + + + + + + + + + + + + + + + + t h e + e u r o p e a n + c o m m i s s i o n + g r a n t e d + c o m e t r i q + c o n d i t i o n a l + a p p r o v a l + f o r + t h e + % 0 a + + + + + + t r e a t m e n t + o f + a d u l t + p a t i e n t s + w i t h + p r o g r e s s i v e % 2 c + u n r e s e c t a b l e + l o c a l l y + % 0 a + + + + + + a d v a n c e d + o r + m e t a s t a t i c + m t c + s i m i l a r + t o + a n o t h e r + d r u g + a p p r o v e d + i n + t h i s + % 0 a + + + + + + s e t t i n g % 2 c + t h e + a p p r o v e d + i n d i c a t i o n + s t a t e s + t h a t + f o r + p a t i e n t s + i n + w h o m + % 0 a + + + + + + r e a r r a n g e d + d u r i n g + t r a n s f e c t i o n + % 2 8 r e t % 2 9 + m u t a t i o n + s t a t u s + i s + n o t + k n o w n + o r + i s + % 0 a + + + + + + n e g a t i v e % 2 c + a + p o s s i b l e + l o w e r + b e n e f i t + s h o u l d + b e + t a k e n + i n t o + a c c o u n t + b e f o r e + % 0 a + + + + + + i n d i v i d u a l + t r e a t m e n t + d e c i s i o n s % 0 a % 0 a % 0 a + + + + + + + + + + + + + + + + + + % 0 a + + + + + + + + i m p o r t a n t + s a f e t y + i n f o r m a t i o n % 2 c + i n c l u d i n g + b o x e d + w a r n i n g s % 0 a + + + + + + % 0 a % 0 a + + + + + + + + + + + + + + + + + + % 0 a + + + + + + + + w a r n i n g % 3 a + p e r f o r a t i o n s + a n d + f i s t u l a s % 2 c + a n d + h e m o r r h a g e % 0 a + + + + + + % 0 a % 0 a + + + + + + + + % 0 a + + + + + + + + + + s e r i o u s + a n d + s o m e t i m e s + f a t a l + g a s t r o i n t e s t i n a l + p e r f o r a t i o n s + a n d % 0 a f i s t u l a s + o c c u r + i n + c o m e t r i q - t r e a t e d + p a t i e n t s % 0 a + + + + + + + + % 0 a % 0 a + + + + + + + + + + % 0 a + + + + + + + + + + s e v e r e + a n d + s o m e t i m e s + f a t a l + h e m o r r h a g e + o c c u r s + i n + c o m e t r i q - t r e a t e d % 0 a p a t i e n t s % 0 a + + + + + + + + % 0 a % 0 a + + + + + + + + + + % 0 a + + + + + + + + c o m e t r i q + t r e a t m e n t + r e s u l t s + i n + a n + i n c r e a s e + i n + t h r o m b o t i c + e v e n t s % 2 c + s u c h + % 0 a + + + + + + + + a s + h e a r t + a t t a c k s % 0 a + + + + + + % 0 a % 0 a + + + + + + + + + + % 0 a + + + + + + + + w o u n d + c o m p l i c a t i o n s + h a v e + b e e n + r e p o r t e d + w i t h + c o m e t r i q % 0 a + + + + + + % 0 a % 0 a + + + + + + + + + + % 0 a + + + + + + + + c o m e t r i q + t r e a t m e n t + r e s u l t s + i n + a n + i n c r e a s e + i n + h y p e r t e n s i o n % 0 a + + + + + + % 0 a % 0 a + + + + + + + + + + % 0 a + + + + + + + + o s t e o n e c r o s i s + o f + t h e + j a w + h a s + b e e n + o b s e r v e d + i n + c o m e t r i q - t r e a t e d + % 0 a + + + + + + + + p a t i e n t s % 0 a + + + + + + % 0 a % 0 a + + + + + + + + + + % 0 a + + + + + + + + p a l m a r - p l a n t a r + e r y t h r o d y s e s t h e s i a + s y n d r o m e + % 2 8 p p e s % 2 9 + o c c u r s + i n + p a t i e n t s + % 0 a + + + + + + + + t r e a t e d + w i t h + c o m e t r i q % 0 a + + + + + + % 0 a % 0 a + + + + + + + + + + % 0 a + + + + + + + + t h e + k i d n e y s + c a n + b e + a d v e r s e l y + a f f e c t e d + b y + c o m e t r i q + p r o t e i n u r i a + a n d + % 0 a + + + + + + + + n e p h r o t i c + s y n d r o m e + h a v e + b e e n + r e p o r t e d + i n + p a t i e n t s + r e c e i v i n g + c o m e t r i q % 0 a + + + + + + % 0 a % 0 a + + + + + + + + + + % 0 a + + + + + + + + r e v e r s i b l e + p o s t e r i o r + l e u k o e n c e p h a l o p a t h y + s y n d r o m e + h a s + b e e n + o b s e r v e d + % 0 a + + + + + + + + w i t h + c o m e t r i q % 0 a + + + + + + % 0 a % 0 a + + + + + + + + + + % 0 a + + + + + + + + a v o i d + a d m i n i s t r a t i o n + o f + c o m e t r i q + w i t h + a g e n t s + t h a t + a r e + s t r o n g + c y p 3 a 4 + % 0 a + + + + + + + + i n d u c e r s + o r + i n h i b i t o r s % 0 a + + + + + + % 0 a % 0 a + + + + + + + + + + % 0 a + + + + + + + + c o m e t r i q + i s + n o t + r e c o m m e n d e d + f o r + u s e + i n + p a t i e n t s + w i t h + m o d e r a t e + o r + % 0 a + + + + + + + + s e v e r e + h e p a t i c + i m p a i r m e n t % 0 a + + + + + + % 0 a % 0 a + + + + + + + + + + % 0 a + + + + + + + + c o m e t r i q + c a n + c a u s e + f e t a l + h a r m + w h e n + a d m i n i s t e r e d + t o + a + p r e g n a n t + w o m a n % 0 a + + + + + + % 0 a % 0 a + + + + + + a d v e r s e + r e a c t i o n s + % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 3 + t h e + m o s t + c o m m o n l y + r e p o r t e d + a d v e r s e + d r u g + r e a c t i o n s + % 0 a + + + + + + % 2 8 g r e a t e r - t h a n + o r + e q u a l + t o + 2 5 % 2 5 % 2 9 + a r e + d i a r r h e a % 2 c + s t o m a t i t i s % 2 c + p a l m a r - p l a n t a r + e r y t h r o d y s e s t h e s i a + % 0 a + + + + + + s y n d r o m e + % 2 8 p p e s % 2 9 % 2 c + d e c r e a s e d + w e i g h t % 2 c + d e c r e a s e d + a p p e t i t e % 2 c + n a u s e a % 2 c + f a t i g u e % 2 c + % 0 a + + + + + + o r a l + p a i n % 2 c + h a i r + c o l o r + c h a n g e s % 2 c + d y s g e u s i a % 2 c + h y p e r t e n s i o n % 2 c + a b d o m i n a l + p a i n % 2 c + % 0 a + + + + + + a n d + c o n s t i p a t i o n + t h e + m o s t + c o m m o n + l a b o r a t o r y + a b n o r m a l i t i e s + % 2 8 g r e a t e r - t h a n + o r + e q u a l + t o + 2 5 % 2 5 % 2 9 + a r e + % 0 a + + + + + + i n c r e a s e d + a s t % 2 c + i n c r e a s e d + a l t % 2 c + l y m p h o p e n i a % 2 c + i n c r e a s e d + a l k a l i n e + % 0 a + + + + + + p h o s p h a t a s e % 2 c + h y p o c a l c e m i a % 2 c + n e u t r o p e n i a % 2 c + t h r o m b o c y t o p e n i a % 2 c + % 0 a + + + + + + h y p o p h o s p h a t e m i a % 2 c + a n d + h y p e r b i l i r u b i n e m i a % 0 a % 0 a % 0 a + + + + + + + + + + + + + + + + + + p l e a s e + s e e + f u l l + u s + p r e s c r i b i n g + i n f o r m a t i o n % 2 c + i n c l u d i n g + b o x e d + w a r n i n g s % 2 c + % 0 a + + + + + + a t + w w w c o m e t r i q c o m % 2 f d o w n l o a d s % 2 f c o m e t r i q _ f u l l _ p r e s c r i b i n g _ i n f o r m a t i o n p d f + % 0 a + + + + + + p l e a s e + r e f e r + t o + t h e + f u l l + e u r o p e a n + s u m m a r y + o f + p r o d u c t + c h a r a c t e r i s t i c s + f o r + % 0 a + + + + + + f u l l + e u r o p e a n + u n i o n + p r e s c r i b i n g + i n f o r m a t i o n % 2 c + i n c l u d i n g + c o n t r a i n d i c a t i o n % 2 c + % 0 a + + + + + + s p e c i a l + w a r n i n g s + a n d + p r e c a u t i o n s + f o r + u s e + a t + w w w s o b i c o m + % 0 a + + + + + + o n c e + p o s t e d % 0 a % 0 a % 0 a + + + + + + + + + + + + + + + + + + % 0 a + + + + + + + + a b o u t + e x e l i x i s % 0 a + + + + + + % 0 a % 0 a + + + + + + + + + + + + + + + + + + e x e l i x i s % 2 c + i n c + i s + a + b i o p h a r m a c e u t i c a l + c o m p a n y + c o m m i t t e d + t o + d e v e l o p i n g + % 0 a + + + + + + s m a l l + m o l e c u l e + t h e r a p i e s + f o r + t h e + t r e a t m e n t + o f + c a n c e r + e x e l i x i s + i s + % 0 a + + + + + + f o c u s i n g + i t s + d e v e l o p m e n t + a n d + c o m m e r c i a l i z a t i o n + e f f o r t s + p r i m a r i l y + o n + % 0 a + + + + + + c o m e t r i q % c 3 % 8 2 % c 2 % a e + % 2 8 c a b o z a n t i n i b % 2 9 % 2 c + i t s + w h o l l y - 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