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w e e k + p e r i o d + i n + t h i s + c o m p a r a t i v e + s t u d y + a r e + v e r y + p r o m i s i n g + w h e n + c o m b i n e d + w i t h + t h e + o t h e r + c l i n i c a l + b e n e f i t s % 2 c + t h e + d a t a + s u g g e s t s + t h a t + t h i s + c l a s s + o f + a g e n t s + m a y + p r o v i d e + a n + a d d i t i o n a l + a n d + v a l u a b l e + t r e a t m e n t + o p t i o n + f o r + p e o p l e + w i t h + t y p e + 2 + d i a b e t e s % 2 2 % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a t h e + g l o b a l + p h a s e + 3 + c a n a g l i f l o z i n + c l i n i c a l + p r o g r a m + e n r o l l e d + m o r e + t h a n + 1 0 % 2 c 3 0 0 + p a t i e n t s + i n + n i n e + s t u d i e s % 2 c + a n d + i s + t h e + l a r g e s t + l a t e - s t a g e + d e v e l o p m e n t + p r o g r a m + f o r + a n + i n v e s t i g a t i o n a l + p h a r m a c o l o g i c + p r o d u c t + f o r + t h e + t r e a t m e n t + o f + t y p e + 2 + d i a b e t e s + s u b m i t t e d + t o + h e a l t h + a u t h o r i t i e s + t o + d a t e + t h e + p h a s e + 3 + c l i n i c a l + p r o g r a m + e v a l u a t e d + t h e + s a f e t y + a n d + e f f i c a c y + o f + c a n a g l i f l o z i n + a c r o s s + t h e + s p e c t r u m + o f + t y p e + 2 + d i a b e t e s + m a n a g e m e n t % 2 c + f r o m + a d u l t + p a t i e n t s + t r e a t e d + o n l y + w i t h + d i e t + a n d + e x e r c i s e + t o + t h o s e + r e q u i r i n g + i n s u l i n + i n j e c t i o n s + t o + m a i n t a i n + g l y c e m i c + c o n t r o l + t h e + p r o g r a m + a l s o + i n c l u d e d + t h r e e + l a r g e + s t u d i e s + i n + s p e c i a l + p o p u l a t i o n s % 3 a + o l d e r + p a t i e n t s + w i t h + t y p e + 2 + d i a b e t e s % 2 c + p a t i e n t s + w i t h + t y p e + 2 + d i a b e t e s + w h o + h a d + m o d e r a t e + r e n a l + i m p a i r m e n t % 2 c + a n d + p a t i e n t s + w i t h + t y p e + 2 + d i a b e t e s + w h o + h a v e + o r + w e r e + c o n s i d e r e d + t o + b e + a t + h i g h + r i s k + f o r + c a r d i o v a s c u l a r + d i s e a s e + o n + m a y + 3 1 % 2 c + 2 0 1 2 % 2 c + j a n s s e n + s u b m i t t e d + a + n e w + d r u g + a p p l i c a t i o n + t o + t h e + u s + f o o d + a n d + d r u g + a d m i n i s t r a t i o n + s e e k i n g + a p p r o v a l + f o r + t h e + u s e + o f + c a n a g l i f l o z i n + a s + a + t r e a t m e n t + f o r + a d u l t + p a t i e n t s + w i t h + t y p e + 2 + d i a b e t e s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 2 2 t h e + r e s u l t s + i n + e a c h + o f + t h e s e + s t u d i e s + s u g g e s t + t h a t + c a n a g l i f l o z i n + c o u l d + p r o v i d e + a n + e f f e c t i v e + t h e r a p e u t i c + o p t i o n + f o r + a d u l t s + w i t h + t y p e + 2 + d i a b e t e s + i n + a + r a n g e + o f + c l i n i c a l + s e t t i n g s % 2 c % 2 2 + s a i d + k i r k + w a y s % 2 c + m d % 2 c + p h d % 2 c + v i c e + p r e s i d e n t + a n d + c o m p o u n d + d e v e l o p m e n t + t e a m + l e a d e r + f o r + c a n a g l i f l o z i n + a t + j a n s s e n + % 2 2 c a n a g l i f l o z i n + h a s + t h e + p o t e n t i a l + t o + b e + a d m i n i s t e r e d + a s + m o n o t h e r a p y + i n + p a t i e n t s + w h o + a r e + i n a d e q u a t e l y + c o n t r o l l e d + w i t h + d i e t + a n d + e x e r c i s e + a l o n e % 2 c + a s + a n + a d d - o n + t h e r a p y + i n + p a t i e n t s + b e i n g + t r e a t e d + w i t h + m e t f o r m i n + a l o n e + o r + i n + c o m b i n a t i o n + w i t h + s u l f o n y l u r e a s % 2 c + a n d + i n + p a t i e n t s + w i t h + m o d e r a t e + r e n a l + i m p a i r m e n t + a s + p a r t + o f + o u r + c o m m i t m e n t + t o + d e v e l o p + n e w + t h e r a p e u t i c + o p t i o n s + f o r + u n m e t + p a t i e n t + n e e d s + i n + t h e + t r e a t m e n t + o f + t y p e + 2 + d i a b e t e s % 2 c + w e + l o o k + f o r w a r d + t o + p r e s e n t i n g + d a t a + f r o m + t h e + r e m a i n i n g + p h a s e + 3 + c a n a g l i f l o z i n + c l i n i c a l + t r i a l s + i n + t h e + n e a r + f u t u r e % 2 2 % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a a b o u t + t h e + s t u d i e s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a d i a 3 0 1 5 + i s + a + 5 2 - w e e k + r a n d o m i z e d % 2 c + d o u b l e - b l i n d % 2 c + a c t i v e - c o n t r o l l e d + p h a s e + 3 + s t u d y + i n + 7 5 5 + a d u l t + p a t i e n t s + w i t h + i n a d e q u a t e + g l y c e m i c + c o n t r o l + o n + m a x i m a l l y + e f f e c t i v e + d o s e s + o f + m e t f o r m i n + a n d + s u l f o n y l u r e a + p a t i e n t s + w e r e + g i v e n + o n c e - d a i l y + d o s e s + o f + c a n a g l i f l o z i n + % 2 8 3 0 0 + m g % 2 9 + o r + s i t a g l i p t i n + % 2 8 1 0 0 + m g % 2 9 + p a t i e n t s + t r e a t e d + w i t h + c a n a g l i f l o z i n + h a d + a + s u b s t a n t i a l + a n d + s u s t a i n e d + d e c r e a s e + i n + a 1 c + l e v e l s % 2 c + w i t h + a + s i g n i f i c a n t l y + g r e a t e r + r e d u c t i o n + r e l a t i v e + t o + s i t a g l i p t i n + a f t e r + 5 2 + w e e k s + % 2 8 - 0 3 7 % 2 c + 9 5 % 2 5 + c i + - 0 5 0 % 3 b + - 0 2 5 % 2 9 + b a s e d + o n + p r o t o c o l - s p e c i f i e d + w i t h d r a w a l + c r i t e r i a % 2 c + m o r e + s u b j e c t s + d i s c o n t i n u e d + f r o m + t h e + s t u d y + d u e + t o + l o s s + o f + g l y c e m i c + c o n t r o l + i n + t h e + s i t a g l i p t i n + t r e a t m e n t + a r m + % 2 8 2 2 5 % 2 5 % 2 9 + t h a n + t h e + c a n a g l i f l o z i n + a r m + % 2 8 1 0 6 % 2 5 % 2 9 + i n + t h e + k e y + s e c o n d a r y + e n d p o i n t + m e a s u r e s % 2 c + p a t i e n t s + t r e a t e d + w i t h + c a n a g l i f l o z i n + 3 0 0 + m g + a l s o + h a d + g r e a t e r + w e i g h t + l o s s + c o m p a r e d + t o + s i t a g l i p t i n + % 2 8 p e r c e n t + c h a n g e s + o f + - 2 5 + a n d + 0 3 % 2 c + r e s p e c t i v e l y % 2 9 % 3 b + r e d u c t i o n s + i n + f a s t i n g + p l a s m a + g l u c o s e + c h a n g e s + w e r e + c o n s i s t e n t + w i t h + t h e + p r i m a r y + a 1 c + e n d p o i n t + % 2 8 - 2 9 9 + a n d + - 5 9 + m g % 2 f d l % 2 c + r e s p e c t i v e l y % 2 9 % 3 b + s y s t o l i c + b l o o d + p r e s s u r e + w a s + r e d u c e d + w i t h + c a n a g l i f l o z i n + % 2 8 - 5 1 + a n d + 0 9 + m m h g % 2 c + r e s p e c t i v e l y % 2 9 + c a n a g l i f l o z i n + r a i s e d + h d l - c + r e l a t i v e + t o + s i t a g l i p t i n + % 2 8 % 2 5 + c h a n g e % 2 c + 7 6 + a n d + 0 6 % 2 c + r e s p e c t i v e l y % 2 9 + % 2 c + a n d + a l s o + l d l - c + % 2 8 % 2 5 + c h a n g e + 1 1 7 + a n d + 5 2 % 2 c + r e s p e c t i v e l y % 2 9 % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a t h e + o v e r a l l + i n c i d e n c e + o f + t r e a t m e n t - e m e r g e n t + a d v e r s e + e v e n t s + % 2 8 a e s % 2 9 + w a s + s i m i l a r + i n + t h e + c a n a g l i f l o z i n + % 2 8 7 6 7 % 2 5 % 2 9 + a n d + s i t a g l i p t i n + % 2 8 7 7 5 % 2 5 % 2 9 + g r o u p s + t h e + i n c i d e n c e + o f + s e r i o u s + a e s + w e r e + l o w + a n d + s i m i l a r + i n + b o t h + g r o u p s + % 2 8 6 4 % 2 5 + a n d + 5 6 % 2 5 % 2 c + a n d + r e s p e c t i v e l y % 2 c + i n + t h e + c a n a g l i f l o z i n + a n d + s i t a g l i p t i n + g r o u p s % 2 9 % 3 b + d i s c o n t i n u a t i o n s + d u e + t o + a e s + w e r e + l o w + i n + b o t h + g r o u p s + b u t + h i g h e r + i n + t h e + c a n a g l i f l o z i n + t h a n + i n + t h e + s i t a g l i p t i n + g r o u p + % 2 8 5 3 % 2 5 % 2 c + a n d + 2 9 % 2 5 % 2 c + r e s p e c t i v e l y % 2 9 + a e s + r e l a t e d + t o + g e n i t a l + m y c o t i c + i n f e c t i o n s + i n + m e n + a n d + w o m e n % 2 c + a n d + a e s + r e l a t e d + t o + a n + o s m o t i c + d i u r e s i s + s u c h + a s + i n c r e a s e d + u r i n a t i o n % 2 c + w e r e + m o r e + f r e q u e n t + i n + p a t i e n t s + t r e a t e d + w i t h + c a n a g l i f l o z i n + t h a n + s i t a g l i p t i n % 3 b + a + s i m i l a r + i n c i d e n c e + o f + u r i n a r y + t r a c t + i n f e c t i o n s + w a s + s e e n + i n + t h e + t w o + t r e a t m e n t + g r o u p s + t h e + g e n i t a l + i n f e c t i o n s + a n d + o s m o t i c + d i u r e s i s + r e l a t e d + a e s + w e r e + g e n e r a l l y + m i l d + t o + m o d e r a t e + i n + i n t e n s i t y + a n d + i n f r e q u e n t l y + l e d + t o + d i s c o n t i n u a t i o n % 3 b + m o s t + g e n i t a l + i n f e c t i o n s + r e s p o n d e d + t o + t o p i c a l + o r + o r a l + a n t i f u n g a l + t h e r a p y + a + s i m i l a r + i n c i d e n c e + o f + h y p o g l y c e m i c + e p i s o d e s + w a s + r e p o r t e d + w i t h + c a n a g l i f l o z i n + a n d + s i t a g l i p t i n % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a t o + a c c e s s + t h e + a b s t r a c t % 2 c + v i s i t + + % 0 d % 0 a h t t p % 3 a % 2 f % 2 f w w w a b s t r a c t s o n l i n e c o m % 2 f p l a n % 2 f s t a r t a s p x % 3 f m k e y % 3 d % 2 5 7 b 0 f 7 0 4 1 0 f - 8 d f 3 - 4 9 f 5 - a 6 3 d - 3 1 6 5 3 5 9 f 5 3 7 1 % 2 5 7 d + + + + + a n d + s e a r c h + f o r + a b s t r a c t + n u m b e r + 5 0 - l b % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a d i a 3 0 0 9 + i s + a + 5 2 - w e e k + r a n d o m i z e d % 2 c + d o u b l e - b l i n d % 2 c + a c t i v e - c o n t r o l l e d + p h a s e + 3 + t r i a l + i n + 1 % 2 c 4 5 0 + a d u l t + p a t i e n t s + w i t h + i n a d e q u a t e + g l y c e m i c + c o n t r o l + o n + m a x i m a l l y + e f f e c t i v e + d o s e s + o f + m e t f o r m i n + p a t i e n t s + w e r e + r a n d o m i z e d + a n d + t r e a t e d + o n c e + d a i l y + w i t h + e i t h e r + c a n a g l i f l o z i n + % 2 8 1 0 0 + m g + o r + 3 0 0 + m g % 2 9 + o r + g l i m e p i r i d e + % 2 8 w i t h + u p - t i t r a t i o n + o f + g l i m e p i r i d e + a l l o w e d + t h r o u g h o u t + t h e + 5 2 - w e e k + p e r i o d % 2 9 + p a t i e n t s + t r e a t e d + w i t h + c a n a g l i f l o z i n + h a d + a + s u s t a i n e d + d e c r e a s e + i n + a 1 c % 2 c + w i t h + s t a t i s t i c a l l y + g r e a t e r + a 1 c - l o w e r i n g + f o r + c a n a g l i f l o z i n + 3 0 0 + m g + a f t e r + 5 2 + w e e k s + w h e n + c o m p a r e d + t o + g l i m e p i r i d e + % 2 8 - 0 9 3 % 2 5 + a n d + - 0 8 1 % 2 5 % 2 c + r e s p e c t i v e l y % 2 c + w i t h + t h e + b e t w e e n + g r o u p + d i f f e r e n c e + o f + - 0 1 2 % 2 5 % 2 c + 9 5 % 2 5 + c i + - 0 2 2 % 3 b + - 0 0 2 % 2 9 % 3 b + t h e + d e c r e a s e + i n + a 1 c + w i t h + c a n a g l i f l o z i n + 1 0 0 + m g + % 2 8 - 0 8 2 % 2 5 % 2 9 + w a s + s i m i l a r + t o + t h a t + f o r + g l i m e p i r i d e + % 2 8 b e t w e e n + g r o u p + d i f f e r e n c e + o f + - 0 0 1 % 2 5 % 2 c + 9 5 % 2 5 + c i + - 0 1 1 % 2 c + 0 0 9 % 2 9 + i n + t h e + k e y + s e c o n d a r y + e n d p o i n t + m e a s u r e s % 2 c + b o t h + t h e + 3 0 0 + m g + a n d + 1 0 0 + m g + c a n a g l i f l o z i n + d o s e + g r o u p s + p r o v i d e d + r e d u c t i o n s + i n + b o d y + w e i g h t % 2 c + w i t h + n o + n o t a b l e + c h a n g e + i n + t h e + g l i m e p i r i d e + g r o u p + % 2 8 b o d y + w e i g h t + % 2 5 + c h a n g e % 2 c + - 4 7 + a n d + - 4 2 + a n d + 1 0 % 2 c + r e s p e c t i v e l y % 2 9 + h y p o g l y c e m i a + e p i s o d e s + o c c u r r e d + a t + a + l o w + i n c i d e n c e + w i t h + c a n a g l i f l o z i n + 3 0 0 + m g + a n d + 1 0 0 + m g % 2 c + a n d + a t + a + h i g h e r + i n c i d e n c e + w i t h + g l i m e p i r i d e + % 2 8 % 2 5 + o f + p a t i e n t s + w i t h + 1 + o r + m o r e + e p i s o d e s % 3 a 4 9 + a n d + 5 6 + a n d + 3 4 2 % 2 9 % 2 8 % 2 5 + o f + p a t i e n t s + w i t h + 1 + o r + m o r e + e p i s o d e s % 3 a r e s p e c t i v e l y % 2 9 + r e d u c t i o n s + i n + f a s t i n g + p l a s m a + g l u c o s e + w e r e + c o n s i s t e n t + w i t h + t h e + p r i m a r y + e n d p o i n t + f o r + c a n a g l i f l o z i n + 3 0 0 + m g + a n d + 1 0 0 + m g + a n d + g l i m e p i r i d e + % 2 8 - 2 7 5 + a n d + - 2 4 3 + a n d + - 1 8 3 + m g % 2 f d l % 2 c + r e s p e c t i v e l y % 2 9 % 3 b + o t h e r + s e c o n d a r y + e n d p o i n t s + i n c l u d e d + r e d u c t i o n s + i n + s y s t o l i c + b l o o d + p r e s s u r e + w i t h + b o t h + d o s e s + o f + c a n a g l i f l o z i n + a n d + n o + n o t a b l e + c h a n g e + w i t h + g l i m e p i r i d e + % 2 8 - 4 6 + a n d + - 3 3 + a n d + 0 2 + m m h g % 2 c + r e s p e c t i v e l y % 2 9 % 3 b + h d l - c + i n c r e a s e d + w i t h + b o t h + 3 0 0 + m g + a n d + 1 0 0 + m g + d o s e s + o f + c a n a g l i f l o z i n % 2 c + w i t h + n o + n o t a b l e + c h a n g e + w i t h + g l i m e p i r i d e + % 2 8 % 2 5 + c h a n g e % 2 c + 9 0 + a n d + 7 9 + a n d + 0 3 % 2 c + r e s p e c t i v e l y % 2 9 % 3 b + l d l - c + r o s e + w i t h + b o t h + d o s e s + o f + c a n a g l i f l o z i n + m o r e + t h a n + w i t h + g l i m e p i r i d e + % 2 8 % 2 5 + c h a n g e % 2 c + 1 4 1 + a n d + 9 6 + a n d + 5 0 % 2 c + r e s p e c t i v e l y % 2 9 % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a t h e + i n c i d e n c e + o f + a e s + a n d + d i s c o n t i n u a t i o n s + d u e + t o + a e s + w e r e + g e n e r a l l y + s i m i l a r + a c r o s s + a l l + t r e a t m e n t + a r m s + a e s + w e r e + m i l d + t o + m o d e r a t e + a n d + t h e + o v e r a l l + i n c i d e n c e + w a s + b a l a n c e d + a c r o s s + t r e a t m e n t + a r m s + a d v e r s e + e v e n t s + r e l a t e d + t o + o s m o t i c + d i u r e s i s + s u c h + a s + i n c r e a s e d + u r i n a t i o n % 2 c + g e n i t a l + m y c o t i c + i n f e c t i o n s + i n + m e n + a n d + w o m e n % 2 c + a n d + u r i n a r y + t r a c t + i n f e c t i o n s + w e r e + m o r e + f r e q u e n t + i n + p a t i e n t s + t r e a t e d + w i t h + c a n a g l i f l o z i n + t h a n + g l i m e p i r i d e % 3 b + t h e s e + s p e c i f i c + a d v e r s e + e v e n t s + w e r e + g e n e r a l l y + m i l d + o r + m o d e r a t e + i n + i n t e n s i t y + a n d + i n f r e q u e n t l y + l e d + t o + d i s c o n t i n u a t i o n % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a t o + a c c e s s + t h e + a b s t r a c t % 2 c + v i s i t + + % 0 d % 0 a h t t p % 3 a % 2 f % 2 f w w w a b s t r a c t s o n l i n e c o m % 2 f p l a n % 2 f s t a r t a s p x % 3 f m k e y % 3 d % 2 5 7 b 0 f 7 0 4 1 0 f - 8 d f 3 - 4 9 f 5 - a 6 3 d - 3 1 6 5 3 5 9 f 5 3 7 1 % 2 5 7 d + + + + + a n d + s e a r c h + f o r + a b s t r a c t + n u m b e r + 3 8 - l b % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a j a n s s e n + p r e s e n t e d + r e s u l t s + f r o m + t h r e e + a d d i t i o n a l + p h a s e + 3 + s t u d i e s + a t + t h i s + y e a r % 2 7 s + a d a + m e e t i n g % 2 c + w h i c h + a l s o + d e m o n s t r a t e + t h e + p o t e n t i a l + v a l u e + o f + c a n a g l i f l o z i n + a c r o s s + t h e + s p e c t r u m + o f + t y p e + 2 + d i a b e t e s + m a n a g e m e n t + i n c l u d i n g + u s e + i n + m o n o t h e r a p y % 2 c + i n + a d d - o n + c o m b i n a t i o n % 2 c + a n d + i n + p a t i e n t s + w i t h + m o d e r a t e + r e n a l + i m p a i r m e n t % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 2 2 c a n a g l i f l o z i n % 2 c + a + s o d i u m + g l u c o s e + c o - 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